Orly Weinreb Selected Research

Monoamine Oxidase (MAO)

1/2017	Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells.
1/2016	Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease.
3/2015	Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging.
9/2013	Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators.
8/2012	Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.
4/2012	Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment.
3/2011	Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim.
1/2011	Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease.
1/2011	A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor.
1/2010	Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.

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Orly Weinreb Research Topics

Disease

29	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2017 - 03/2004
22	Alzheimer Disease (Alzheimer's Disease) 09/2017 - 09/2004
20	Parkinson Disease (Parkinson's Disease) 03/2015 - 04/2003
10	Schizophrenia (Dementia Praecox) 01/2017 - 06/2006
9	Neuroblastoma 01/2017 - 05/2003
9	Hypoxia (Hypoxemia) 02/2014 - 01/2005
8	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017 - 03/2004
8	Dementia (Dementias) 04/2012 - 12/2006
7	Inflammation (Inflammations) 12/2014 - 09/2004
5	Lewy Body Disease (Lewy Body Dementia) 01/2010 - 10/2006
4	Cognitive Dysfunction 01/2017 - 03/2004
3	Neuroinflammatory Diseases 10/2017 - 01/2016
3	Mitochondrial Diseases (Mitochondrial Disease) 02/2016 - 02/2007
2	Basal Ganglia Diseases (Basal Ganglia Disease) 04/2012 - 01/2011
2	Nervous System Diseases (Neurological Disorders) 10/2008 - 01/2008
2	Pheochromocytoma 08/2005 - 09/2004
2	Ischemia 04/2005 - 01/2005
2	Craniocerebral Trauma (Head Injury) 04/2005 - 01/2005
1	Glaucoma 01/2018
1	Retinoblastoma (Glioblastoma, Retinal) 01/2018
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 10/2017
1	Neurobehavioral Manifestations 01/2017
1	Atrophy 01/2017
1	Disease Progression 01/2015
1	Type 2 Diabetes Mellitus (MODY) 12/2014
1	Brain Hypoxia (Cerebral Hypoxia) 12/2014
1	Hepatocellular Carcinoma (Hepatoma) 01/2013
1	Hallucinations (Hallucination) 01/2013
1	Memory Disorders (Memory Loss) 09/2012
1	Amyloid Plaque 05/2012
1	Gliosis 04/2012
1	Mood Disorders (Mood Disorder) 03/2011

Drug/Important Bio-Agent (IBA)

29	IronIBA 10/2017 - 03/2004
22	Pharmaceutical PreparationsIBA 01/2018 - 09/2004
20	Neuroprotective AgentsIBA 10/2017 - 04/2003
17	rasagiline (Azilect)FDA Link 01/2017 - 09/2004
17	Monoamine Oxidase (MAO)IBA 01/2017 - 09/2004
13	Chelating AgentsIBA 02/2016 - 09/2004
10	Proteins (Proteins, Gene)FDA Link 01/2017 - 04/2003
10	AntioxidantsIBA 09/2013 - 05/2003
10	PolyphenolsIBA 01/2012 - 05/2003
10	TeaIBA 01/2011 - 05/2003
9	Antipsychotic Agents (Antipsychotics)IBA 01/2017 - 06/2006
9	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamateIBA 04/2012 - 10/2006
8	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2016 - 03/2004
7	Cholinesterases (Cholinesterase)IBA 01/2017 - 10/2006
6	propargylamineIBA 09/2017 - 04/2005
6	NeurotoxinsIBA 11/2009 - 04/2003
5	Dopamine (Intropin)FDA LinkGeneric 01/2017 - 04/2003
5	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 04/2012 - 06/2006
5	Antidepressive Agents (Antidepressants)IBA 04/2012 - 05/2008
4	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 01/2017 - 12/2006
4	MetalsIBA 02/2016 - 09/2004
4	Amyloid (Amyloid Fibrils)IBA 01/2016 - 10/2006
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017 - 08/2005
3	Rivastigmine (Exelon)FDA LinkGeneric 01/2017 - 10/2006
3	Fluvoxamine (Luvox)FDA LinkGeneric 01/2017 - 06/2011
3	Therapeutic UsesIBA 01/2017 - 01/2011
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 10/2016 - 01/2010
3	EnzymesIBA 01/2016 - 08/2007
3	GABA-A Receptors (GABA(A) Receptor)IBA 05/2015 - 06/2011
3	N-propargylIBA 08/2012 - 01/2010
3	FlavonoidsIBA 01/2012 - 03/2004
3	Levodopa (L Dopa)FDA LinkGeneric 11/2010 - 01/2005
3	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2009 - 09/2008
3	Messenger RNA (mRNA)IBA 02/2009 - 08/2005
3	Complementary DNA (cDNA)IBA 12/2004 - 04/2003
2	5- (2- (methylprop- 2- ynylamino)ethyl)quinolin- 8- olIBA 10/2017 - 01/2017
2	Glutamic Acid (Glutamate)FDA Link 02/2016 - 01/2016
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 03/2015 - 01/2007
2	Oxyquinoline (8 Hydroxyquinoline)FDA Link 08/2012 - 01/2010
2	methyl carbamateIBA 04/2012 - 01/2010
2	Free RadicalsIBA 01/2012 - 01/2011
2	Selegiline (E250)FDA LinkGeneric 01/2010 - 11/2009
2	CatalaseIBA 02/2009 - 09/2008
2	Catechin (Z 7300)IBA 10/2008 - 01/2008
1	BromidesIBA 01/2018
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2017
1	Scopolamine (Hyoscine)FDA Link 01/2017
1	Serotonin (5 Hydroxytryptamine)IBA 01/2017
1	Biological ProductsIBA 10/2016
1	Superoxide DismutaseIBA 02/2016
1	Peptides (Polypeptides)IBA 01/2016
1	gamma-Aminobutyric Acid (GABA)IBA 05/2015
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 03/2015
1	Oxidopamine (6 Hydroxydopamine)IBA 03/2015
1	Fructose-Bisphosphate Aldolase (Aldolase)IBA 02/2014
1	Insulin (Novolin)FDA Link 02/2014
1	Insulin ReceptorIBA 02/2014
1	Glucose (Dextrose)FDA LinkGeneric 02/2014
1	Mixed Function Oxygenases (Monooxygenases)IBA 01/2014
1	SynucleinsIBA 09/2013
1	Ferritins (Ferritin)IBA 01/2013
1	Presenilin-1IBA 09/2012
1	Acetylcholine (Acetylcholine Chloride)FDA Link 04/2012
1	Streptozocin (Streptozotocin)FDA Link 04/2012
1	lactacystinIBA 03/2011
1	Drug CombinationsIBA 01/2011

Therapy/Procedure

6	Therapeutics 01/2015 - 02/2007
1	Denervation 01/2017